Kritische Blicke auf die Coronakrise und ihre Folgen
Kritische Blicke auf die Coronakrise und ihre Folgen

Chronic Fatigue Syndrome among Children and Adolescents

Anna-Lisa Sorg, Selina Becht, Marietta Jank u. a.: Association of SARS-CoV-2 Seropositivity With Myalgic Encephalomyelitis and/or Chronic Fatigue Syndrome Among Children and Adolescents in Germany, in: JAMA Network Open Vol. 5, Issue 9 (September 27, 2022) p. e2233454, online in:

Key Points

The authors asked, if SARS-CoV-2 seropositivity is associated with symptoms of myalgic encephalomyelitis and/or chronic fatigue syndrome (ME/CFS) in children and adolescents.

In their cross-sectional study of hospital-based SARS-CoV-2 seroprevalence surveys in Germany the authors compared seropositive and seronegative children and adolescents and identified an excess of possible ME/CFS symptoms with serological evidence of preceding SARS-CoV-2 infection. This association almost disappeared with adjustment for confounders and restriction to children and adolescents unaware of preceding infection.

The findings suggest that the risk of ME/CFS after SARS-CoV-2 infection in children and adolescents may be small and that recall bias may contribute to risk estimates.

Link to the article on the JAMA Network site

Link to download the article from the JAMA Network site