Daily archives: 7. July 2022

Khadija Khan et al.: Omicron sub-lineages BA.4/BA.5 escape BA.1 infection elicited neutralizing immunity, in: medRxiv (May 1, 2022), online in: https://doi.org/10.1101/2022.04.29.22274477. Abstract The SARS-CoV-2 Omicron (B.1.1.529) variant first emerged as the BA.1 sub-lineage, with extensive escape from neutralizing immunity elicited by previous infection with other variants, vaccines, or combinations of both. Two new sub-lineages, BA.4 and BA.5, were emerging in South Africa with changes relative to BA.1, including L452R and F486V mutations in the spike receptor binding domain. The authors isolated live BA.4 and BA.5 viruses and tested them against neutralizing immunity elicited to BA.1 infection in participants who were […]