Daily archives: 20. January 2022

2 posts

Omicron, Comirnaty and ACE2

Sandile Cele u. a.: SARS-CoV-2 Omicron has extensive but incomplete escape of Pfizer BNT162b2 elicited neutralization and requires ACE2 for infection, Dezember 17, 2021, online in: https://doi.org/10.1101/2021.12.08.21267417. The emergence of SARS-CoV-2 Omicron, first identified in Botswana and South Africa, may compromise vaccine effectiveness and the ability of antibodies triggered by previous infection to protect against re-infection. Here the authors investigated whether Omicron escapes antibody neutralization in South Africans, either previously SARS-CoV-2 infected or uninfected, who were vaccinated with Pfizer BNT162b2. They also investigated if Omicron requires the ACE2 receptor to infect cells.

Antibody Potency & Omicron

Daniel J. Sheward, Changil Kim, Roy A. Ehling, Alec Pankow, View ORCID ProfileXaquin Castro Dopico, Darren Martin, Sai Reddy, Joakim Dillner, Gunilla B. Karlsson Hedestam, Jan Albert, Ben Murrell: New Results. Variable loss of antibody potency against SARS-CoV-2 B.1.1.529 (Omicron) [Preprint], December 20, 2021. The recently-emerged SARS-CoV-2 B.1.1.529 variant (Omicron) is spreading rapidly in many countries, with a spike that is highly diverged from the pandemic founder, raising fears that it may evade neutralizing antibody responses. The authors cloned the Omicron spike from a diagnostic sample which allowed us to rapidly establish an Omicron pseudotyped virus neutralization assay, sharing initial […]